m-PEG10-azide a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 2112738-12-0

Molecular Weight: 497.58

Formula: C21H43N3O10

Chemical Name: 31-azido-2,5,8,11,14,17,20,23,26,29-decaoxahentriacontane

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

InChiKey: JIJUYQJOYRMNAR-UHFFFAOYSA-N

InChi: InChI=1S/C21H43N3O10/c1-25-4-5-27-8-9-29-12-13-31-16-17-33-20-21-34-19-18-32-15-14-30-11-10-28-7-6-26-3-2-23-24-22/h2-21H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

1. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Products are for research use only. Not for human use.