Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). eCollection 2020.Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro. Alpelisib Plus Letrozole Shows Promise After CDK 4/6 Inhibitor Therapy in PIK3CA-Mutated HR+/HER2- Advanced Breast Cancer.

Product information

CAS Number: 1217486-61-7

Molecular Weight: 441.47

Formula: C19H22F3N5O2S

Synonym:

Alpelisib

BYL 719

BYL719

Chemical Name: (2S)-N1-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide

Smiles: CC(C)(C1=CC(=CC=N1)C1SC(NC(=O)N2CCC[C@H]2C(N)=O)=NC=1C)C(F)(F)F

InChiKey: STUWGJZDJHPWGZ-LBPRGKRZSA-N

InChi: InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.