PNRI-299 is a selective AP-1 transcription inhibitor with an IC50 of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-κB transcription (up to 200 uM) or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model.

Product information

CAS Number: 550368-41-7

Molecular Weight: 401.37

Formula: C21H15N5O4

Chemical Name: N-benzyl-2-(3-cyanophenyl)-1,3,7-trioxo-1H,2H,3H,7H,8H-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxamide

Smiles: N#CC1C=C(C=CC=1)N1C(=O)N2CC(=O)C=C(C(=O)NCC3C=CC=CC=3)N2C1=O

InChiKey: UPQJVNPKWQFAKQ-UHFFFAOYSA-N

InChi: InChI=1S/C21H15N5O4/c22-11-15-7-4-8-16(9-15)25-20(29)24-13-17(27)10-18(26(24)21(25)30)19(28)23-12-14-5-2-1-3-6-14/h1-10H,12-13H2,(H,23,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.